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pHLIP peptides target acidity in activated macrophages
The reverse Warburg effect in osteosarcoma
Increased iron in brain tissue causes reactive oxygen species (ROS) formation via Fenton reaction, inducing ferroptosis and finally leading to neurodegeneration (Kim et al., 2015
Evidence tier by reported use The single most useful way to read this pair is not which peptide is stronger but which specific use has which tier of evidence. The table below maps each commonly discussed use to its strongest available evidence and an honest interpretation
Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus